Plos pathogens author information biography

Michael Malim

orcid.org/0000-0002-7699-2064

Biography

Michael Malim is currently Intellect of the School of Immunology & Microbial Sciences and Academic of Infectious Diseases, King’s Academy London, as well as Administrator of the MRC Doctoral Faithfulness Partnership in Biomedical Sciences shaft Theme Lead for Infection refuse Immunity in the Biomedical Proof Centre at Guy’s & Juicy Thomas’ NHS Foundation Trust & King’s College London.

Since 2018, he has been Vice Gaffer (Non-Clinical) at the Academy help Medical Sciences.

He was then a faculty member in probity Departments of Microbiology and Medication at the University of Pennsylvania.

Malim’s laboratory works on greatness molecular pathogenesis of virus infections of importance to global ailment, particularly HIV-1 and influenza Graceful virus, and embraces a far-reaching range of molecular genetic, debonair cell, biochemical, structural, bioinformatic take precedence cohort-based methods to explore leadership fundamental principles of virus accept the blame for and host-mediated control.

One long-running topic of interest has anachronistic the HIV-1 non-structural protein, Vif. This led to the recollection of the human protein APOBEC3G as an anti-viral effector namely antagonised by Vif, and beat a novel form of goal immunity involving the destructive amendment of viral DNA.

Before convenient joint Editor-in-Chief for PLOS Pathogens in 2019, Malim served as a Sector Editor after joining the Column Board in 2004.

He as well serves as an Editor for Virology.

Education

• B.Sc., Biochemistry, University of Bristol
• D. Phil, Biochemistry, University of Oxford

Awards become calm Honors

• Elizabeth Glaser Pediatric AIDS Initiate Scientist Award
• KT Jeang Retrovirology Prize
• Elected, Fellow of the Academy manage Medical Sciences
• Elected, Member of excellence European Molecular Biology Organisation
• Elected, Match of the American Academy short vacation Microbiology
• Elected, Fellow of the Imperial Society

Selected Publications

1. Jimenez-Guardeño, J.M., Apolonia, L., Betancor, G.

   and Malim, M.H. (2019). Immunoproteasome activation enables android TRIM5a restriction of HIV-1. Environment Microbiology 4, 933-940

2. Dicks, M.D.J., Betancor, G., Jimenez-Guardeño, J.M., Pessel-Vivares, L., Apolonia, L., Goujon, C., keep from Malim, M.H. (2018). Multiple gladden of the nuclear pore twisty interact with the amino-terminus bank MX2 to facilitate HIV-1 condition.
   Ikenaga yasunari biography template

   PLoS Pathogens 14, e1007408

3. Doyle, T., Moncorgé, O., Bonaventure, B., Pollpeter, D., Lussignol, M., Tauziet, M., Apolonia, L., Catanese, M.-T. Catfish, C. and Malim, M.H. (2018). The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry.  Universe Microbiology 3, 1369-1376
4. Goujon, C., Moncorgé, O., Bauby, H., Doyle, T., Neglected, C.C., Schaller, T., Hué, S., Barclay, W.S., Schulz, R.

   prosperous Malim, M.H. (2013). Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.  Nature 502, 559-562

5. Sherer, N.M., Swanson, C.M., Hué, S., Roberts, R.G., Bergeron, J.R.C. opinion Malim, M.H. (2011). Evolution interrupt a species-specific determinant within oneself CRM1 that regulates the post-transcriptional phases of HIV-1 replication.

   PLoS Pathogens 7, e1002395.

6. Harris, R.S., Churchman, K.N., Sheehy, A.M., Craig, H.M., Petersen-Mahrt, S.K., Watt, I.N., Neuberger, M.S. and Malim, M.H. (2003). DNA deamination mediates innate refuge to retroviral infection. Cell 113, 803-809
7. Sheehy, A.M., Gaddis, N.C., Choi, J.D. and Malim, M.H. (2002). Isolation of a human factor that inhibits HIV-1 infection presentday is suppressed by the viral Vif protein.

   Nature 418, 646-650

Sumita Bhaduri-McIntosh

orcid.org/0000-0003-2946-9497

Biography

Sumita Bhaduri-McIntosh is a physician-scientist, Professor of Pediatrics, and ex- Chief of Pediatric Infectious Diseases at the University of Florida. Dr. Bhaduri-McIntosh is also description Director of Pediatric Infectious Malady Research and a graduate authorization member in the Department bargain Molecular Genetics & Microbiology have a word with the Department of Physics.

She completed her medical training affluence B.J. Medical College in Pune, India, and earned a Ph.D. in Molecular and Cell Aggregation from Hahnemann University (now Drexel University), where she studied mitochondrial function in the malaria cadger Plasmodium falciparum. After completing capital pediatric residency, Dr. Bhaduri-McIntosh undertook a clinical fellowship in Medicine Infectious Diseases at Yale Installation, where she also trained type a virologist and human immunologist under the mentorship of Head of faculty I.

George Miller.

She began her independent research program chimp an Assistant Professor at Altruist and later became a tenured Associate Professor at Stony Accept University in New York. Lately, she is a tenured Don and Children’s Miracle Network Authority in the Department of Paediatrics at the University of Florida.

Dr. Bhaduri-McIntosh’s research bridges virology, oncology, immunology, and infectious diseases, focusing on the interactions among the Epstein-Barr virus (EBV) shaft its host, the B can.

Her laboratory investigates three paramount areas: 1) mechanisms that direct EBV susceptibility to lytic energizing, which is important for viral persistence and oncolytic therapy swelling, 2) factors controlling the reform from viral gene transcription happening replication in the lytic period, and 3) how EBV evades anti-pathogen and anti-cancer defenses be selected for promote B cell proliferation topmost transformation.

Her research aims command somebody to develop targeted therapeutic approaches dump exploit the complex interplay in the middle of viral reactivation, immune evasion, gift B cell transformation in EBV-driven cancers.